Endocrine Abstracts

With an aging population the number of total joint replacements performed due to end-stage osteoarthritis is increasing. Critically, a significant proportion of patients report dissatisfaction following surgery, with around 10% of hip and 20% of knee OA patients developing chronic postoperative pain. Obesity is a well-known risk factor for the development of OA. Pre-surgical obesity has been previously associated with worse clinical outcomes following arthroplasty. Therefore, ...

Introduction: It is essential that children and young people with diabetes are supported to manage their diabetes effectively to prevent the development of early complications. However, the common clinical challenge is difficultly in engaging adolescents and young people to achieve good glycaemic control in their diabetes management. Solution Focus Therapy (SFBT) has been found to be especially beneficial with children, adolescents and teenagers because it is a brief model tra...

Aim: The aim of this study was to evaluate hormonal disturbances and adipokines levels in girls with oligomenorrhea.Materials and methods: The study comprised a group of 46 girls, aged 16–18 years, who were diagnosed with oligomenorrhea, and a control group with 37 healthy girls, aged 16–18 years, with no diagnosed menstrual disorders. In the first stage of the study, all girls had their medical history assessed. Subsequently, anthropometric me...

Objectives: The objective was to evaluate effects of hyperthyroidism and hypothyroidism on bone metabolism in premenopausal women with special emphasis to osteoprotegerin (OPG) and vitamin D3 (vD).Materials and methods: A total of 119 women aged 18–52 years were studied (38 with recently diagnosed hyperthyroidism; 40 with newly diagnosed hypothyroidism; 41 healthy women as controls). Patients were followed up for a period of 1 year. BMD, ...

University Hospitals Dorset (UHD) has over 1,000 thyroid patient contacts annually. These are primarily patients with autoimmune hyperthyroidism and are treated by titration of Carbimazole. Dose adjustments are made by a healthcare professional (HCP) based on the results of thyroid function tests. Once the test results are available, the HCP decides on a prescription dose and communicates this to the patient, which is time-consuming and introduces delays. This project aims to ...

Introduction: Asprosin, a novel adipokine, is a circulating hormone mainly secreted by white adipose tissue. Asprosin is encoded by the penultimate 2 exons of the fibrillin 1 (FBN1) gene. Protein product of FBN1 is profibrillin-1, which undergoes a proteolytic cleavage by furin enzyme to produce mature fibrillin-1 and asprosin. Literature data indicated that asprosin is involved in the development of diabetes, obesity, cardiomyopathy, cancer, and polycystic o...

Both therapeutic glucocorticoids (GCs) and chronic inflammation are powerful inducers of systemic bone loss, resulting in osteoporosis and increased morbidity. Whilst GCs suppress inflammation, it is unclear how these factors interact to determine net bone metabolism. We investigated the balance between osteo-protective and osteo-destructive properties of GCs in the TNF-tg model of chronic inflammatory disease. Wild-type (WT) and TNF-tg mice were treated with corticosterone (1...

The aim of the study was to analyze the influence of feed from different production systems on food intake, body chemical composition and plasma leptin concentrations in rats. It is expected, that organically produced feed influences positively rat organism, in that hormone balance. Leptin regulates energy intake and expenditure, as well as basic functions of many tissues.The experiment was conducted in 104 Wistar male rats divided into 16 dietary groups...

To maintain proper fertility the balance between formation and luteolysis of corpus luteum (CL) are necessary and strictly controlled events in female reproduction. Degeneration of CL is correlated with apoptosis and autophagy as well as connected with decreased progesterone (P4) level. Resistin is a new key player in the regulation of luteal cells function; our previously study showed that resistin have negative effect on P4 synthesis. Thus the aim of the present study was to...

Introduction: Turner syndrome (TS) is characterized by the complete or partial loss of one X chromosome and associated with a wide range of clinical manifestations. The clinical appearance depends on the specific karyotype, which may include different mosaic forms. Main features of almost all the karyotypes are short stature and delayed or absent puberty. Adult women in particular are at high risk of developing cardiac complications, metabolic syndrome, increased liver enzyme ...